The Amazon is practically synonymous with South America, covering about 40 percent of the continent and touching eight (out of 12 total) countries. The eponymous river and surrounding rainforest are the lifeblood of this part of the planet, home to more than 40,000 plant species and 1,300 bird species alone. Book a river cruise or stay at a remote eco-lodge to best experience this natural wonder of the world.

You’ve no doubt seen photos of Salar de Uyuni during the wet season—when rainfall hits the massive salt flat, the space becomes a sky-reflecting mirror that is absolutely beloved by photographers. But the flat is worth visiting during dry spells as well, as it resembles a perfectly horizontal sheet of hexagonal salt tiles.

It may be one of the most recognizable landmarks on the planet, but seeing Machu Picchu in person will take your breath away. Try to visit before dawn—either by hiking the Inca Trail or taking a bus in from Aguas Calientes—to watch the sun slowly cast its morning light over the ruins.

Located more than 300 miles off the western coast of Colombia, this mile-long island and its surrounding marine environment has been a UNESCO site since 2006. It’s widely recognized as one of the world’s top diving sites, particularly for people looking to swim with sharks—aggregations of 200 hammerhead sharks and 1,000 silky sharks have been recorded in these waters.

Rio de Janeiro is easily one of the most beautiful places in South America—and one of the most beautiful cities in the world—thanks entirely to its spectacular natural surroundings and world-class beaches. There’s nothing quite like lounging on the sands of Copacabana or Ipanema, sitting in the shadow of the iconic Sugarloaf Mountain while the sounds of the city thrum in the background.

San Carlos de Bariloche (or Bariloche, for short) sits in the foothills of the Andes in the Patagonia region. With its ski lifts and chocolate shops, it could easily be mistaken for a charming town in the Swiss Alps.

Just two hours west of Medellín, this small Andean town is famed for its rainbow-colored streets and stunning views from an adjacent inselberg, El Peñol. The landmark rock features a rather grueling 659-step climb to the top, but it’s very much worth it for the panoramic vistas of the surrounding reservoir and verdant hills.

You’ll be hard-pressed to find a town with a more beautiful setting than Baños, a small community situated in the shadow of an active volcano and surrounded by waterfalls, dense forests, and the Amazon Basin. Baños is perhaps best known for “the swing at the end of the world,” an Instagram-famous rope swing that more than earns its nickname.